From A66, exit "Miquelallee", towards Frankfurt – Innenstadt, follow Reuterweg and Taunusanlage, turn left into Junghofstrasse and right again into "Neue Schlesingergasse".
From A5 towards "Westkreuz" and exit onto the A648. From there, drive towards Frankfurt - Innenstadt – Messe and follow the signs to the central railway station (Hauptbahnhof).
There, turn left into "Mainzer Landstrasse", then right into "Junghofstrasse" and right again into "Neue Schlesingergasse".